Research & Clinical Studies
Advancing care through evidence, collaboration, and continuous learning
Research at RML Specialty Hospital is closely connected to patient care. Clinical studies focus on improving long-term acute care for medically complex patients who continue to need hospital-level support after critical illness, with particular emphasis on respiratory care, ventilator weaning, and complex recovery.
Findings from research are used to inform how care is delivered, reviewed, and refined across the hospital—supporting thoughtful, evidence-informed decision-making without predicting individual outcomes.
Why Research Matters at RML
Patients in long-term acute care often experience prolonged and complex recoveries that require careful clinical judgment over time. Research helps care teams better understand these challenges and evaluate approaches in real-world hospital settings.
At RML, research supports interdisciplinary collaboration, ongoing review of safety and quality, and continuous learning across clinical teams. Findings are used to guide care planning and evaluation, not to define timelines or guarantee results.
Core Areas of Research Focus
Research at RML is organized around clinical areas where patients face the greatest complexity and need for ongoing hospital-level care. These focus areas reflect both the scope of care provided and the responsibility to continually evaluate and improve practice.
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Ventilator Weaning & Respiratory Care Research
Research in respiratory care examines patterns of prolonged ventilator dependence, interdisciplinary approaches to ventilator weaning, and clinical considerations during extended recovery. This work contributes to a deeper understanding of how ventilator-dependent patients progress through hospital-level care.
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Medical Rehabilitation & Complex Recovery Studies
Studies in this area explore recovery following critical illness, particularly for patients with multisystem conditions or extended medical needs. Research addresses functional recovery, endurance challenges, and longer-term considerations that influence care planning during prolonged hospitalization.
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Clinical Outcomes & Quality Improvement Research
Outcomes-focused research supports quality improvement initiatives and interdisciplinary review across the hospital. This work informs care coordination, safety monitoring, and continuous evaluation of clinical practices in long-term acute care settings.
Research Studies & Clinical Trials (List of case Studies)
Prolonged Ventilator Weaning
Effect of Pressure Support vs Unassisted Breathing Through a Tracheostomy Collar on Weaning Duration in Patients Requiring Prolonged Mechanical Ventilation, one of the largest ventilator-weaning studies of its kind, was published in the Journal of the American Medical Association and led by Amal Jubran, MD.
This landmark study examined different approaches to ventilator weaning for patients requiring prolonged mechanical ventilation (more than 21 days). Researchers compared pressure-support ventilation with unassisted breathing through a tracheostomy collar.
The study contributed to clinical understanding of how different weaning approaches may affect the weaning process in long-term acute care settings. Findings from this research have informed how ventilator-weaning care is evaluated and approached in hospital-level LTCH environments.
Research findings help guide care practices; individual patient experiences and recovery paths vary.
Ventilator Weaning and Quality of Life Research Topics
RML summarizes a range of studies examining quality of life during ventilator use and the weaning process, including findings published in Long-Term Outcome and Functional Status of Patients Weaned from Prolonged Mechanical Ventilation.
These studies explore topics such as:
- How prolonged mechanical ventilation may affect quality of life
- Physical strength and respiratory muscle function during weaning
- Factors associated with longer-term outcomes after ventilator weaning
- Patient-reported quality-of-life considerations following weaning
This body of research helps broaden understanding of recovery beyond the immediate medical process.
Psychosocial Aspects of Weaning
Studies summarized by RML examine:
- Anxiety levels in patients weaned from mechanical ventilation
- Early signs of post-traumatic stress symptoms in patients recovering from prolonged ventilation
These findings highlight the importance of considering emotional well-being alongside physical recovery during long-term acute care.
Other Ventilator-Weaning Studies
Additional research has examined specific clinical experiences related to mechanical ventilation, including:
- Whether mechanically ventilated patients are able to perceive airway secretions
- Outcomes observed in cohorts of ventilated patients with West Nile virus infection
These studies contribute to a broader understanding of patient experiences and clinical considerations during prolonged ventilation.
COVID-19 Research
RML has participated in COVID-19–related research efforts examining care considerations for patients requiring long-term acute care.
This includes:
- A collaborative study with Rush University exploring correlations between coronavirus cultures and PCR test results
- Participation in a national study led by the National Association of Long Term Hospitals examining outcomes for LTCH patients with COVID-19
This research supports continued learning about complex recovery needs following COVID-19–related critical illness.
Contributing to Industry-Wide Research
In collaboration with long-term acute care hospitals across the country, RML served as a primary contributor to Post-ICU Mechanical Ventilation at Long-Term Hospitals: A Multicenter Outcomes Study.
Sponsored by the National Association of Long Term Hospitals, this research examined ventilator-dependent patients over a one-year period. Areas of analysis included:
- Patient demographics and severity of illness
- Diagnoses associated with ventilator dependence
- Weaning attempts and time-to-wean observations
- Length of stay and functional status
- Disposition and quality-of-life measures
This multicenter research contributes to broader industry understanding of care patterns in long-term acute care hospitals.
ReInvigorate Clinical Trial – Sponsor Stimdina Medical, Inc
This prospective, multi-center, randomized, controlled clinical trial evaluates the safety and efficacy of the pdSTIM System, a device designed to support ventilator weaning through phrenic nerve stimulation.
Funding: Stimdina Medical, Inc.
IMPROVE Clinical Trial – Nasal Antisepsis for Candida auris – Sponsor RUSH/CDC Prevention Epicenter Project
This randomized, controlled, open-label clinical trial examines the effect of 10% povidone-iodine intranasal antisepsis on the detection of Candida auris, an emerging multidrug-resistant organism of concern in healthcare settings.
The study contributes to broader infection prevention and surveillance efforts aimed at reducing the spread of antimicrobial-resistant organisms.
Funding: CDC U54CK000607 (Hayden MK, PI)
Air Monitoring in Collaboration with Chicago Department of Public Health
This public health monitoring initiative is designed to assess trends in airborne pathogens using a novel air-sampling device.
The activity evaluates the presence of respiratory viruses—including SARS-CoV-2, influenza, and other respiratory pathogens—to support broader public health surveillance and infection monitoring efforts.
Partner: Chicago Department of Public Health (CDPH)
Sewer Monitoring for Antimicrobial Resistance Trends (SMART) – Sponsors RUSH/CDC SHEPheRD Contract
This research initiative assesses the feasibility and usefulness of detecting multidrug-resistant organisms through wastewater sampling from long-term care facilities.
The study supports public health efforts to better understand antimicrobial resistance trends and environmental surveillance approaches in healthcare-associated settings.
Partners: CDC / RUSH
Muscle Strength Training in Patients Experiencing Voicing Difficulties After Prolonged Mechanical Ventilation
This clinical initiative explores the use of inspiratory and expiratory muscle strength training devices in patients who experience voicing difficulties following prolonged mechanical ventilation.
The work examines supportive strategies that may assist patients facing communication challenges during recovery after extended ventilator use.
Epidemiological Analysis of Candida auris in a Long-Term Acute Care Hospital
This ongoing epidemiological analysis examines the clinical impact of patients admitted to a long-term acute care hospital who are colonized with Candida auris.
Initial findings from this work were presented at the NALTH Spring 2024 LTCH Clinical Education Conference in Nashville, Tennessee (March 27–29).
How Research Informs Care at RML
Research findings support how care teams collaborate, reassess patient needs, and review care approaches across disciplines. This integration reinforces evidence-informed practice while maintaining focus on individualized, hospital-level care.
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